Advances in Understanding Kingella kingae (SpringerBriefs in by Joseph W. St. Geme III

By Joseph W. St. Geme III

This publication describes the turning out to be physique of data at the epidemiology, scientific manifestations, transmission, pathogenesis, analysis, and remedy of Kingella kingae infections in teenagers. furthermore, it covers experimental equipment which were constructed to check the microbiology, genetics, and virulence elements of K. kingae, details that offers the root for brand spanking new ways to therapy and prevention of K. kingae disease. With this content material in brain, excerpts from the e-book should be of relevance for clinicians who take care of pediatric sufferers, for medical microbiologists who're fascinated about detecting organisms in scientific specimens, and for scientists who're learning K. kingae in an attempt to enhance novel goals for antimicrobial treatment and new ways to prevention.

First remoted within the Sixties through Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae was principally missed over the following 20 years as a human pathogen as a result of its unusual restoration from sufferers with disorder. besides the fact that, in fresh years K. kingae has been more and more famous as a clinically very important pathogen in teenagers, and is at the moment well-known because the major explanation for osteoarticular infections in little ones in progressively more nations. examine into this organism has grown significantly during the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of disease. 

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Kingae type IV pili mediate adherence to respiratory epithelial cells [2]. The density of piliation correlates with three different colony morphologies when K. kingae is grown on solid medium: a spreading/corroding colony type associated with expression of abundant phase variable pili, a non-spreading/noncorroding colony type associated with sparse pili, and a domed colony type associated with no pili [3, 4]. Type IV pili are found in a wide variety of gram-negative species, with examples including enteropathogenic Escherichia coli, Salmonella enterica serovar typhi, Pseudomonas aeruginosa, Legionella pneumophila, Neisseria gonorrhoeae, Neisseria meningitidis, and Vibrio cholerae.

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Basmaci R, Ilharreborde B, Bidet P, Doit C, Lorrot M, Mazda K, Bingen E, Bonacorsi S (2012) Isolation of Kingella kingae in the oropharynx during K. kingae arthritis in children. Clin Microbiol Infect 18(5):E134–E136. x 30. Yagupsky P, Peled N, Katz O (2002) Epidemiological features of invasive Kingella kingae infections and respiratory carriage of the organism. J Clin Microbiol 40(11):4180–4184 31. El Houmami N, Minodier P, Dubourg G, Mirand A, Jouve JL, Basmaci R, Charrel R, Bonacorsi S, Yagupsky P, Raoult D, Fournier PE (2015) Patterns of Kingella kingae disease outbreaks.

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