Advances in Pharmacology by Silvio Garattini and Parkhurst A. Shore (Eds.)

By Silvio Garattini and Parkhurst A. Shore (Eds.)

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Possibly these fluids do not contain active kinins, but a kinin is released from kininogen when glass activates a kininogenase in the system (Keele and Armstrong, 1964). On the other hand, a material, which was probably active kinin, was found in the peritoneal cavity of mice during a “squirming” response (Whittle, 1964). Hot water treatment of the skin can also release a bradykinin-like substance subcutaneously. , 1959) (this certainly would be the first instance when hypnosis or another type of persuasion would hold back a kinin release).

Bradykinin and kallidin are about equally potent in increasing capillary permeability, but another kinin, wasp venom kinin, might be even more active (Schachter, 1963b). Two bradykiniri derivatives, the hexa- and the octapeptides, were 30 to 100 times less effective than the parent compound (Burckhardt, 1962). Edema forniation in the rat paw, which follows the adiiiinistration of bradykinin, can be blocked by some antiphlogistic agents (Lisin and Leclercq, 1963), but this type of drug was ineffective in the rabbit skin (Friinnier and Iirych, 1963).

1963a,b,c), but some other investigators disagree (Keele and Armstrong, 1964). The release of kinin in the forearm was not attributed by Chapnian to the function of sweat glands (R. H. Fox and Hilton, 1958), or to permeability changes (Hilton, 1963; Chapman and Goodell, 1964). , 1961). , 1960c; Keele and Armstrong, 1964) or intraarterial injection of bradykinin causes pain (R. H. , 1961; Burch and De Pasquale, 1962). , 196313). , 1964b). , 1961; Mitchell and Krell, 1964). Kallikrein causes severe itching when administered intradermally (Cormia and Dougherty, 1960).

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