Advances in Immunology, Vol. 59 by Frank J. Dixon (Ed.)

By Frank J. Dixon (Ed.)

With contributions from Steven A. Porcelli and different the world over famous leaders within the box, this quantity maintains the culture of fundamental stories. Papers at the CD1 relatives, optimistic number of thymocytes, and molecular and mobile facets of XLA spotlight the most recent quantity.

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Extra resources for Advances in Immunology, Vol. 59

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3. Consensus residues indicate the most common amino acid occurring at each position. An X denotes that no residue occurs more than once at that position. Alignments were performed as described in the legend to Fig. 3. Dashes indicate gaps that have been introduced to maximize alignments. Residues that match the CDl consensus sequence are shaded and boxed. , 1987). Double horizontal lines beneath the a3 domain sequences indicate an area in MHC class I molecules involved in the interaction with CD8.

1994). , 1986). , 1991). The demonstration of /32-microglobulin association with CDla heavy chains was initially complicated by conflicting results, although subsequent studies have entirely resolved the resulting controversy and confusion. , 1979). , 1984). Subsequently, it was shown that C Dla isolated from cultured MOLT-4 cell lysates does associate with a 12kDa subunit, although this subunit was reported to be electrophoretically distinct from human P2-microglobulin. This apparently unique “P2-microglobulin-like” small polypeptide was termed PT (Ziegler and Milstein, 1979).

Thus, in their overall pattern of cellular expression group 1 CD1 proteins are distinctly unlike the ubiquitously expressed classical MHC class I molecules and more closely parallel the restricted pattern of expression characteristic of MHC class 11. , CDld) have been less well studied, but initial observations suggest that their tissue distribution may be at least as widespread as that of the group 1CD1 proteins, with one unique feature being their expres- THE CD1 FAMILY 55 sion on epithelial cells in the gastrointestinal mucosa and elsewhere.

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