Acute Exposure Guideline Levels for Selected Airborne by National Research Council, Division on Earth and Life

By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels

File from the Subcommittee on Acute publicity instruction degrees and the Committee on Toxicology from the Board on Environmental stories and Toxicology. quantity 2. Softcover.

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No further experimental details were available. 8. Sheep A 10-min LC50 value of 333 ppm was determined from exposing groups of two Dorset crossbred wethers to phosgene at concentrations of 135, 240, 427, or 758 ppm for 10 min, followed by a 24-h observation period (Keeler et al. 1990b). Animals that died displayed a mixture of stringy mucous and frothy white material from the proximal trachea to the smaller bronchioles that About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files.

5-h value was then scaled to the 30-min and 1-, 4-, and 8-h AEGL exposure periods using Cn×t=k, where n=1 (Haber’s law), because Haber’s law has been shown to be valid for phosgene within certain limits. Haber’s law was originally derived from phosgene data (Haber 1924). The 30-min value is also adopted as the 10-min value, because extrapolation would yield a 10-min AEGL-2 value approaching concentrations that produce alveolar edema in rats; Diller et al. (1985) observed alveolar pulmonary edema in rats exposed to phosgene at 5 ppm for 10 min.

Please use the print version of this publication as the authoritative version for attribution. APPENDIX 28 eral other acute lethality studies of phosgene in mice have been reported. However, these studies do not contain experimental details such as strain or gender of mouse, number of animals exposed, or analytical methodology. These values, in addition to those of Zwart et al. (1990), are presented in Table 1–6. 2. Rats Zwart et al. (1990) exposed groups of five male and five female Wistar rats to phosgene at varying concentrations for 5, 10, 30, or 60 min.

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